HORDB

ID: hor006550
Uniprot ID: P51923
Protein name: Progonadoliberin-3
Gene name: gnrh3
Organism: Sparus aurata (Gilthead sea bream)
Family: GnRH family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Sparus (genus), Sparidae (family), Spariformes (order), Eupercaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: QHWSYGWLPGGKRSVGELEATIRMMGTGGVVSLPEEASAQTQERLRPYNVIKDDSSPFDRKKRFPNK
Length: 67
Propeptide: MEASSRVTVQVLLLALVVQVTLSQHWSYGWLPGGKRSVGELEATIRMMGTGGVVSLPEEASAQTQERLRPYNVIKDDSSPFDRKKRFPNK
Signal peptide: MEASSRVTVQVLLLALVVQVTLS
Modification: T1 Pyrrolidone carboxylic acid;T10 Glycine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006550_AF2.pdb

hor006550_ESM.pdb

Mass:	876894	Formula:	C334H525N99O100S2
Absent amino acids:	C	Common amino acids:	GRS
pI:	10.16	Basic residues:	12
Polar residues:	20	Hydrophobic residues:	17
Hydrophobicity:	-91.79	Boman Index:	-16742
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	56.72
Instability Index:	6693.43	Extinction Coefficient cystines:	13980
Absorbance 280nm:	211.82

PubMed ID: 9843645
Title: Levels of the native forms of GnRH in the pituitary of the gilthead seabream, Sparus aurata, at several characteristic stages of the gonadal cycle.